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Publication: IIP Proceedings Year: 2022, Month: November Page No: 33-37, ISSN/ISBN: 978-93-95632-96-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl20230CBD96A696E5A42.pdf
THE APPLICATION OF MONOCLONAL ANTIBODIES IN MEDICINE
Area/Stream: Medical Sciences, Authors: Medowelie Mathew, Thokchom Shawankumar Singh Keywords: Monoclonal antibody, hybridoma technology, ELISA, western immunoblotting Book Name /series: Futuristic Trends in Medical Science,Volume 2, Book 22, Part 1, Chapter 6Publication: IIP Proceedings Year: 2022, Month: November Page No: 33-37, ISSN/ISBN: 978-93-95632-96-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl20230CBD96A696E5A42.pdf
Abstract:
An antigen usually has many epitopes and may stimulate specific B-cells and bind to the specific epitope. Each stimulated Bcell undergoes proliferation and produces a clone of B-cells which then differentiates into plasma cells. Plasma cells in turn produce a mixture of antibodies specific to various epitopes. However, if only one particular epitope stimulates one B cell and allowed to proliferate and produce antibodies having the same antigenic specificity, they are referred to as monoclonal antibodies (mAbs). The Hybridoma technology developed in 1975 by Georges J. F. Kohler and C. Milstein produces monoclonal antibodies. Recent research on mAbs have its widespread uses in clinical medicine for both diagnostic and therapeutic purposes. Its uses in ELISA, immunohistochemistry and western immunoblotting have redefined in the diagnosis of various diseases. Uses of mAbs in cancer treatment, immune diseases and many bacterial and viral diseases are increasing. The future prospect of this review is to understand its application in the trend of diseases and its utility in clinical diagnostic and therapeutic fields.
Cite this: Medowelie Mathew, Thokchom Shawankumar Singh,"THE APPLICATION OF MONOCLONAL ANTIBODIES IN MEDICINE", Futuristic Trends in Medical Science,Volume 2, Book 22, Part 1, Chapter 6, November, 2022, 33-37, 978-93-95632-96-6, https://rsquarel.org/assets/docupload/rsl20230CBD96A696E5A42.pdf
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