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Remarkable Anti-Breast Cancer Activity of Ferrocene Tagged Multi-Functionalized 1, 4-Dihydropyrimidines
Area/Stream: Chemistry, Medicine,Pharmacology, Toxicology and Pharmaceutics, Authors: Jagannath Jadhava, Aarti Juvekar, Rajanikant Kuranea, Sharanabasappa Khanapure, Rajashri Salunkhe, Gajanan Rashinkara Keywords: Ferrrocene1, 4-Dihydropyrimidines, Ferrocenyl chalcones, Amidines, Anti breast canceJournal Name: European journal of medicinal chemistry Year:2013, Month:July , Volume: 65, Issue: Page No:232-239, ISSN: 0223-5234, DOI/Link: https://www.sciencedirect.com/science/article/abs/pii/S0223523413002535#kwrds0010Abstract:
A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of 1H NMR, 13C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.
Cite this: Jagannath Jadhava, Aarti Juvekar, Rajanikant Kuranea, Sharanabasappa Khanapure, Rajashri Salunkhe, Gajanan Rashinkara,"Remarkable Anti-Breast Cancer Activity of Ferrocene Tagged Multi-Functionalized 1, 4-Dihydropyrimidines", European journal of medicinal chemistry, 65, , July , 2013, 232-239, 0223-5234, https://www.sciencedirect.com/science/article/abs/pii/S0223523413002535#kwrds0010
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