editedbook
Publication: IIP Proceedings Year: 2022, Month: November Page No: 122-127, ISSN/ISBN: 978-93-95632-67-6, DOI/Link: https://www.rsquarel.org/assets/docupload/rsl2023F22D48286A6086F.pdf
MICROWAVE ASSISTED GREEN SYNTHESIS OF PARACETAMOL, ASPIRIN AND THEIR PHARMACOKINETIC STUDIES
Area/Stream: Chemical, Material Sciences & Nano Technology, Authors: Dr. Ganesh N Yallappa, Dr. Rajendra Prasad S, Prof. Nataraja G Keywords: Paracetamol, Aspirin, Microwave method, Green Chemistry, Pharmacokinetics. Book Name /series: Futuristic Trends in Chemical, Material Sciences & Nano Technology, Volume 2, Book 13, Part 2, Chapter 3Publication: IIP Proceedings Year: 2022, Month: November Page No: 122-127, ISSN/ISBN: 978-93-95632-67-6, DOI/Link: https://www.rsquarel.org/assets/docupload/rsl2023F22D48286A6086F.pdf
Abstract:
The research looks at a new way to make Paracetamol and Aspirin using green chemistry concepts via solvent free reaction and under microwave irradiation. The synthesis was carried out from salicylic acid and 4-aminophenol, acetic anhydride, and no catalyst. The reaction time for both the molecules was low. The yield of Paracetamol is 92.0% and Aspirin is 82.0%. The reaction progression was confirmed by TLC. The structure of the compounds was confirmed by FT-IR and Melting point. Upon literature studies, our work was focussed on the biological metabolism of these synthesized compounds. The compounds were tested for pharmacological studies. We reported the pharmacokinetics and their side effects during the metabolism in the human body. The results were interpreted.
Cite this: Dr. Ganesh N Yallappa, Dr. Rajendra Prasad S, Prof. Nataraja G,"MICROWAVE ASSISTED GREEN SYNTHESIS OF PARACETAMOL, ASPIRIN AND THEIR PHARMACOKINETIC STUDIES", Futuristic Trends in Chemical, Material Sciences & Nano Technology, Volume 2, Book 13, Part 2, Chapter 3, November, 2022, 122-127, 978-93-95632-67-6, https://www.rsquarel.org/assets/docupload/rsl2023F22D48286A6086F.pdf
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