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Publication: IIP Proceedings Year: 2022, Month: November Page No: 245-257`, ISSN/ISBN: 978-93-95632-88-1, DOI/Link: https://rsquarel.org/assets/docupload/rsl20239DCDB4F6A94B907.pdf
ARTEMISININ: AN EFFICIENT ANTIMALARIAL DRUG WITH POTENT ANTI-CANCER PROPERTY
Area/Stream: Biotechnology, Authors: Achinta Gogoi, Hemanta Bordoloi Keywords: Plasmodium falciparum, artemisinin, Artemisia annua L, antimalarial, 1,2,4-trioxane, cancer therapy. Book Name /series: Futuristic Trends in Biotechnology, Volume 2, Book 27, Part 3, Chapter 2Publication: IIP Proceedings Year: 2022, Month: November Page No: 245-257`, ISSN/ISBN: 978-93-95632-88-1, DOI/Link: https://rsquarel.org/assets/docupload/rsl20239DCDB4F6A94B907.pdf
Abstract:
Malaria- a disease that world is familiar with from 19th century, still possessing a great threat to mankind. Many quinine-based drugs are available but their side effects and resistance developed by Plasmodium falciparum strains made this disease a horrendous one. Artemisinin and its derivatives containing 1,2,4-trioxane endoperoxide ring, which was originally extracted from Chinese medicinal plant, Sweet Wormwood (Artemisia annua L), a medicinal plant shows excellent antimalarial activity without adverse effects in patients. Despite having great antimalarial activity, the use of artemisinin for treatment of malaria is obstructed by high IC50 value resulted from poor solubility in oil and water, low blood plasma half-life. As a result, scientists are looking for its semisynthetic derivatives which are found to be more efficient against Plasmodium falciparum malaria. Along with antimalarial activities, later research reveals that artemisinin possesses anticancer properties also, which allows scientists to do extensive research in this field. In this chapter, we are mainly focussing on the brief discovery and invention course of artemisinin, mechanism of action of artemisinin and its derivatives against Plasmodium falciparum, recent advances in this field, and its potential application in cancer therapy.
Cite this: Achinta Gogoi, Hemanta Bordoloi,"ARTEMISININ: AN EFFICIENT ANTIMALARIAL DRUG WITH POTENT ANTI-CANCER PROPERTY", Futuristic Trends in Biotechnology, Volume 2, Book 27, Part 3, Chapter 2, November, 2022, 245-257`, 978-93-95632-88-1, https://rsquarel.org/assets/docupload/rsl20239DCDB4F6A94B907.pdf
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