editedbook
Publication: IIP Proceedings Year: 2022, Month: November Page No: 197-206, ISSN/ISBN: 978-93-95632-76-8, DOI/Link: https://www.rsquarel.org/assets/docupload/rsl20239BA9589DCEE324E.pdf
ADVANTAGES OF HOMOCYSTEINE INDUCED PARKINSON MODEL
Area/Stream: Agriculture Engineering & Food Sciences, Authors: Sagarika Dutta, Pro. Jogen Ch. Kalita Keywords: Homocysteine; PD model; Cysteine; Neurodegeneration; L-Dopa Book Name /series: Futuristic Trends in Agriculture Engineering & Food Sciences, Volume 2, Book 10, Part 3, Chapter 6Publication: IIP Proceedings Year: 2022, Month: November Page No: 197-206, ISSN/ISBN: 978-93-95632-76-8, DOI/Link: https://www.rsquarel.org/assets/docupload/rsl20239BA9589DCEE324E.pdf
Abstract:
Homocysteine; a homologue of the amino acid cysteine is a non-proteinogenic sulphur-containing amino acid. Elevated levels of plasma homocysteine has been reported in PD patients undertaking a treatment of L-DOPA (L-3,4- dihydroxyphenylalanine).The methylation of L-DOPA by catechol-o-methyl transferase is reported as the leading cause of the elevated homocysteine levels in blood plasma in PD patients. The hypothesized mechanisms of neuronal damage by hypehomocystemia appear to be multiple and often overlapping. Reports from various authors has given a conclusion that nervous system might be particularly sensitive to extracellular homocysteine due to its excitotoxic properties.
Cite this: Sagarika Dutta, Pro. Jogen Ch. Kalita,"ADVANTAGES OF HOMOCYSTEINE INDUCED PARKINSON MODEL", Futuristic Trends in Agriculture Engineering & Food Sciences, Volume 2, Book 10, Part 3, Chapter 6, November, 2022, 197-206, 978-93-95632-76-8, https://www.rsquarel.org/assets/docupload/rsl20239BA9589DCEE324E.pdf
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