editedbook
Publication: IIP Proceedings Year: 2022, Month: November Page No: 163-171, ISSN/ISBN: 978-93-95632-86-7 0, DOI/Link: https://rsquarel.org/assets/docupload/rsl20238CFB84E0B63434C.pdf
PRO-DRUG DEVELOPMENTS
Area/Stream: Pharmacy & Nursing, Authors: Keshav Kumar, Dr. Rupali Sharma, Dr. Satish Sardana Keywords: Drug Development Book Name /series: Futuristic Trends in Pharmacy & Nursing,Volume 2, Book 23, Chapter 13Publication: IIP Proceedings Year: 2022, Month: November Page No: 163-171, ISSN/ISBN: 978-93-95632-86-7 0, DOI/Link: https://rsquarel.org/assets/docupload/rsl20238CFB84E0B63434C.pdf
Abstract:
To come out pharmacokinetic & pharmacodynamic limitations of active drugs there is an effective strategy to overcome that is design and developments of prodrugs. A large numbers of prodrugs are already available in market and well established in recent years. Also in recent years there is particular enhance in the use of prodrugs as an advancement of parent drugs for treatment of different types diseases. Prodrugs are modified derivatives of active moiety entered in therapy due to their advantageous physicochemical properties (greater stability, improved solubility, increased permeability,) used in inactive form. Biological effect occurs by the active derivatives formed in organism through chemical transformation (biotransformation). A prodrug strategy includes changes in active moiety and making different derivatives that provides much advantages over parent moiety like enhancing membrane permeability, overcome pharmacokinetic barriers like poor solubility, absorption, rapid excretion and pharmacodynamic barriers such as toxicity, side effects and poor efficacy. site specification, transporter targeting, improving aqueous solubility and so many. Recently, out of pharmaceutical products 10% are available as prodrugs. 50% of prodrugs changed to the active form by hydrolysis mechanism and majorly by hydrolysis of ester. Now we can identify prodrugs produced by chemical derivatisation, bioprecursors and targeted delivery systems
Cite this: Keshav Kumar, Dr. Rupali Sharma, Dr. Satish Sardana,"PRO-DRUG DEVELOPMENTS", Futuristic Trends in Pharmacy & Nursing,Volume 2, Book 23, Chapter 13, November, 2022, 163-171, 978-93-95632-86-7 0, https://rsquarel.org/assets/docupload/rsl20238CFB84E0B63434C.pdf
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