editedbook
Publication: IIP Proceedings Year: 2022, Month: November Page No: 47-56, ISSN/ISBN: 978-93-95632-96-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl202385C6084441F3425.pdf
CURRENT PRACTICE OF PATHOLOGY IN THE MOLECULAR ERA
Area/Stream: Medical Sciences, Authors: Yengkhom Daniel Singh, Thingujam Deeparani, Babina Sarangthem Keywords: Molecular Pathology, modern biology tools, malignancy, multidisciplinary team Book Name /series: Futuristic Trends in Medical Science,Volume 2, Book 22, Part 1, Chapter 8Publication: IIP Proceedings Year: 2022, Month: November Page No: 47-56, ISSN/ISBN: 978-93-95632-96-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl202385C6084441F3425.pdf
Abstract:
Molecular Pathology is defined by the Association of Clinical Pathologists as “the study of molecules in a disease state” by using the tools of molecular biology to better understand the aetiology, pathogenesis, diagnosis and prognosis of diseases. The use of antibody integrated specific immunohistochemical stains marks the dawn of the Molecular era of pathology. This chapter discusses briefly the various modern biology tools used in diagnostics and the role of molecular pathologist in understanding diseases and malignancies in particular as a part of the multidisciplinary team consisting of pathologist, radiologist, clinico-oncologist, surgeon and therapist. The commonly used modern biology tools in diagnostics are Immunohistochemistry, Pyrosequencing, Sanger sequencing, Reverse transcriptase (RT)- PCR, q RT-PCR, FISH, Next-generation sequencing (NGS) targeted panels etc. Newer tools like Liquid biopsy, digital pathology, tissue biobanking, patients derived organoids are also briefly mentioned. The importance of integration of morphological pathology and molecular diagnostics and the need for trained Molecular Pathologist is emphasized here. Molecular pathology is currently of great importance, and is becoming increasingly significant as it enables more precise diagnosis and treatment selection. Hence, the “molecular revolution” has deeply transformed cancer care, re-evaluating the role of the pathologic diagnoses as the backbone of the therapeutic decision-making process. Establishment of a multidisciplinary cancer institute with a single laboratory equipped with both diagnostics and research facilities is the need of the hour.
Cite this: Yengkhom Daniel Singh, Thingujam Deeparani, Babina Sarangthem,"CURRENT PRACTICE OF PATHOLOGY IN THE MOLECULAR ERA", Futuristic Trends in Medical Science,Volume 2, Book 22, Part 1, Chapter 8, November, 2022, 47-56, 978-93-95632-96-6, https://rsquarel.org/assets/docupload/rsl202385C6084441F3425.pdf
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