editedbook
Publication: IIP Proceedings Year: 2022, Month: November Page No: 20-24, ISSN/ISBN: 978-93-95632-96-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl20236F8AFAD612603C7.pdf
THE RELATIONSHIP BETWEEN NESFATIN-1 LEVELS AND VARIOUS DISEASES
Area/Stream: Medical Sciences , Authors: Davina Hijam, Nungshitombi Ngangbam Keywords: Nesfatin-1, nucleobindin2, anorexigenic Book Name /series: Futuristic Trends in Medical Science,Volume 2, Book 22, Part 1, Chapter 4Publication: IIP Proceedings Year: 2022, Month: November Page No: 20-24, ISSN/ISBN: 978-93-95632-96-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl20236F8AFAD612603C7.pdf
Abstract:
Nesfatin-1(NES-1) is a multifunctional polypeptide made up of 82 amino acids and derived from nucleobindin2 (NUCB2) which is a protein. It has 3 parts and the second part consisting of 23-53 amino acids is the active part, which has an anorexigenic effect on food intake and also affects glucose hemostasis, and has an anti-apoptotic and anti- inflammatory effect. Studies have shown that NES-1 is secreted from hypothalamus which are responsible for controlling appetite and also from the peripheral tissues which induces vasoconstriction and decrease gastric motility. The level of NES-1 is decreased in Type 2 Diabetes Mellitus patients compared to the apparently healthy individuals. It has a role in the glucose metabolism, justified by the presence of NES-1 and insulin together in human pancreas. The suggested mechanism here is it increases insulin sensitivity and decreases its resistance. The level of NES-1 has a negative correlation with the body mass index (BMI), HOMA-IR (homeostatic model assessment of insulin resistance), waist-hip ratio and apnea hypopnea index in Metabolic Syndrome patients. The value of NES-1 of Polycystic Ovarian Syndrome patients were lower compared to the healthy individuals. In a study of epilepsy patients, serum NES-1 levels before prescribing antiepileptic treatment were 160 times higher in newly diagnosed patients of generalized seizure than the healthy individuals. The value reduced after the treatment but was still higher than the values of the controls. Hence, nesfatin-1 can be a potential biomarker for the diagnosis and monitoring of epilepsy patients in response to anti- epileptic treatment. The level of NES-1 has a negative relationship with the incidence and severity of coronary artery disease.
Cite this: Davina Hijam, Nungshitombi Ngangbam,"THE RELATIONSHIP BETWEEN NESFATIN-1 LEVELS AND VARIOUS DISEASES", Futuristic Trends in Medical Science,Volume 2, Book 22, Part 1, Chapter 4, November, 2022, 20-24, 978-93-95632-96-6, https://rsquarel.org/assets/docupload/rsl20236F8AFAD612603C7.pdf
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