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Publication: IIP Proceedings Year: 2022, Month: November Page No: 121-126, ISSN/ISBN: 978-93-95632-92-8, DOI/Link: https://rsquarel.org/assets/docupload/rsl2023FFAC870DB271BFC.pdf
ROSAI-DORFMAN DISEASE- A RARE ENTITY
Area/Stream: Medical Sciences, Authors: Dr. Manika Alexander, Dr. Himachal Mishra Keywords: Rosai Dorfman, Disease, Histiocytes Book Name /series: Futuristic Trends in Medical Sciences,Volume 2, Book 21, Part 1, Chapter 14Publication: IIP Proceedings Year: 2022, Month: November Page No: 121-126, ISSN/ISBN: 978-93-95632-92-8, DOI/Link: https://rsquarel.org/assets/docupload/rsl2023FFAC870DB271BFC.pdf
Abstract:
Rosai Dorfman Disease (RDD) is a rare disorder of histiocytes.1 It is predominantly seen in males affecting younger age groups but patients of all the age groups are known to be affected by this disease.2 The most common presentation is bilateral massive lymphadenopathy which is non-tender and self-limiting. Head and neck region as the most commonly affected regions.3 Apart from involvement of lymph nodes in head and neck regions, it has been reported to involve inguinal, retroperitoneal and mediastinal lymph nodes also. Extranodal manifestation has been seen over 40% patients, but it may occur in older patients even in the absence of nodal disease. Exact pathogenesis of RDD has not been known. It was thought to be a reactive, nonneoplastic histiocytic disorder lacking clonality.5 RDD is believed to be a reactive process, and an undefined immunological defect is thought to be initiated by some other organism which is believed to be responsible for this disease. 9 The most common differential for RDD are Langerhans cell histiocytosis (LCH), lymphoma and nonspecific sinus hyperplasia.
Cite this: Dr. Manika Alexander, Dr. Himachal Mishra,"ROSAI-DORFMAN DISEASE- A RARE ENTITY", Futuristic Trends in Medical Sciences,Volume 2, Book 21, Part 1, Chapter 14, November, 2022, 121-126, 978-93-95632-92-8, https://rsquarel.org/assets/docupload/rsl2023FFAC870DB271BFC.pdf
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