editedbook
Publication: IIP Proceedings Year: 2022, Month: November Page No: 112-120, ISSN/ISBN: 978-93-95632-92-8, DOI/Link: https://rsquarel.org/assets/docupload/rsl2023A009AA41235F26C.pdf
ROLE OF MICRO ORGANISMS AS AN ALTERNATIVE ANIMAL MODEL IN THE BIOMEDICAL RESEARCH
Area/Stream: Medical Sciences, Authors: Sangeetha Subramani, Leonal Rabins, Jayasheela, M. Geetha Keywords: Animal welfare, Alternative animal model, C. elegans, yeast and Bacteria Book Name /series: Futuristic Trends in Medical Sciences,Volume 2, Book 21, Part 1, Chapter 13Publication: IIP Proceedings Year: 2022, Month: November Page No: 112-120, ISSN/ISBN: 978-93-95632-92-8, DOI/Link: https://rsquarel.org/assets/docupload/rsl2023A009AA41235F26C.pdf
Abstract:
Significant limitations and rising animal ethical concerns towards welfare of laboratory animals especially using vertebrate animal model for research experimentation studies there is need for alternative methods in the biomedical research. Besides these, the animal experimentation studies involve time requirement, man power and technical support. In addition, animal may suffer from pain and stress throughout the study period. Recently, microorganisms are acceptable as models in metabolism, genetics and biochemistry and they can sometimes serves as models of more complex systems. The use of micro organisms includes C. elegans, Yeast and bacteria (salmonella typhimurium) as an alternative approach for testing and research to animal model achieves relevant advantages, results on both in vivo and in vitro assays. The distinctive characteristics such as microscopic, transparency, small size, short life cycle, makes more reliable to work with it when compared to animal model. As these microbial models have the biochemical pathways are very similar to those of humans, it has been employed in the biomedical research studies. Alternative animal model may significantly reduce the usage of animals for experimentation which fulfill the 3R strategy formulated by Russel and Burch in 1959. Therefore, considering the above importance the alternative approach to animal model provides reliable results like animal models.
Cite this: Sangeetha Subramani, Leonal Rabins, Jayasheela, M. Geetha,"ROLE OF MICRO ORGANISMS AS AN ALTERNATIVE ANIMAL MODEL IN THE BIOMEDICAL RESEARCH", Futuristic Trends in Medical Sciences,Volume 2, Book 21, Part 1, Chapter 13, November, 2022, 112-120, 978-93-95632-92-8, https://rsquarel.org/assets/docupload/rsl2023A009AA41235F26C.pdf
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