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Publication: IIP Proceedings Year: 2022, Month: November Page No: 232-244, ISSN/ISBN: 978-93-95632-83-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl202336BE746CEF97870.pdf
MICROBIAL ANTIMICROBIAL PEPTIDES AS ANTICANCER AGENTS WITH SPECIAL REFERENCE TO THE STREPTOMYCES SPECIES
Area/Stream: Futuristic Trends in Biotechnology, Volume 2, Book 26, Chapter 14, Authors: Akshatha S. J, Dr. Manjula Ishwara Kalyani Keywords: Cancer; Streptomyces Sp.; Antimicrobial peptides; Angiogenesis; Cytotoxic activity; Apoptosis. Book Name /series: Futuristic Trends in Biotechnology, Volume 2, Book 26, Chapter 14Publication: IIP Proceedings Year: 2022, Month: November Page No: 232-244, ISSN/ISBN: 978-93-95632-83-6, DOI/Link: https://rsquarel.org/assets/docupload/rsl202336BE746CEF97870.pdf
Abstract:
Despite improvements in tumour diagnosis and treatment, cancer remains one of the major causes of death globally. Conventional cancer therapies are incapable of treating specific cancer types at different stages since they affect solid and tumour cells leading to side effects and undesirable symptoms. Therefore advanced strategies should be developed to overcome cancer. Streptomyces species have been studied extensively over the past few decades as a result of their exceptional efficiency in generating antimicrobial peptide compounds that are beneficial to human health. The antimicrobial peptides originated from Streptomyces species belongs to different groups including anthracyclines, macrolides, quinones, aminoglycosides and non-ribosomal peptides. These antimicrobial peptides causes DNA cleavage through topoisomerase I and II inhibition, mitochondrial dysfunction, release of cytochrome c molecules, suppression of tumour induced angiogenesis and inhibition of important signal transduction enzymes like proteases or cell metabolism to induce apoptosis. Streptomyces Sp. are widely distributed in nature and can be found in various habitats. The members of these organisms have special attention to produce therapeutic peptide compounds which has strong cytotoxic effect against several human cancer cells. In this review, we explored the anticancer impact represented by Streptomyces Sp. in search for future chemo preventive and anticancer medications”.
Cite this: Akshatha S. J, Dr. Manjula Ishwara Kalyani,"MICROBIAL ANTIMICROBIAL PEPTIDES AS ANTICANCER AGENTS WITH SPECIAL REFERENCE TO THE STREPTOMYCES SPECIES", Futuristic Trends in Biotechnology, Volume 2, Book 26, Chapter 14, November, 2022, 232-244, 978-93-95632-83-6, https://rsquarel.org/assets/docupload/rsl202336BE746CEF97870.pdf
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