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Publication: IIP Proceedings Year: 2022, Month: November Page No: 183-193, ISSN/ISBN: 978-93-95632-92-8, DOI/Link: https://rsquarel.org/assets/docupload/rsl20239DD36E65D39576D.pdf
EVALUATION OF INVITRO AND INSILICO ANTILITHIATIC AND ANTIOXIDANT POTENTIAL WITH THE ACETONIC EXTRACT OF PUNICA GRANATUM WHOLE FRUIT
Area/Stream: Medical Sciences, Authors: M. Mamatha, M. Ganga Raju, NVL Suvarchala Reddy Keywords: Punica granatum, Homogenous and precipitation method, docking. Book Name /series: Futuristic Trends in Medical Sciences ,Volume 2, Book 21, Part 2, Chapter 3Publication: IIP Proceedings Year: 2022, Month: November Page No: 183-193, ISSN/ISBN: 978-93-95632-92-8, DOI/Link: https://rsquarel.org/assets/docupload/rsl20239DD36E65D39576D.pdf
Abstract:
Development of stones anywhere in the urinary sections, are referred to as urolithiasis. The Punicaceae plant family comprises Punica granatum. Pomegranate fruit is utilised in the ailment of diarrhoea, dysentery, and intestinal parasites and has anti-inflammatory and antibacterial qualities. The objectives of our study is to evaluate the antilithiatic activity by in vitro and in silico molecular analysis of an whole fruit acetonic extract of Punica granatum Cystone used as a standard drug in the present study. Plant screening resulted the presence of tannins, terpenoids, alkaloids, glycosides, carbohydrates, saponins and steroids. The acetonic extract of Punica granatum was proved to possess prominent antioxidant activity by reducing power assay. By reducing the concentration of reactive oxygen species i.e. measured by the transformation of Ferric ion to Frrousion, increased absorption of reaction mixture indicates increased reducing power. The Nucleation and aggregation processes of CaC2O crystallisation were both hindered by the administration of PGAE and Cystone coupled with calcium chloride dihydrate; the decrease in solution turbidity in both phenomena indicated percentage inhibition. In vitro anti-lithiatic activity by Homogenous and precipitation method, PGAE and Cystone dissolved calcium oxalate precipitate. The compounds present in Punica granatum whole fruit, acetonic extract they are docked with protein 5G3N. Ellagic acid, Alpha tocopherol, Brevifolin, Kaempferol, Maslinic acid shown good docking score Overall results explain us that PGAE has proven in-vitro anti-lithiatic activity and antioxidant activity.
Cite this: M. Mamatha, M. Ganga Raju, NVL Suvarchala Reddy,"EVALUATION OF INVITRO AND INSILICO ANTILITHIATIC AND ANTIOXIDANT POTENTIAL WITH THE ACETONIC EXTRACT OF PUNICA GRANATUM WHOLE FRUIT", Futuristic Trends in Medical Sciences ,Volume 2, Book 21, Part 2, Chapter 3, November, 2022, 183-193, 978-93-95632-92-8, https://rsquarel.org/assets/docupload/rsl20239DD36E65D39576D.pdf
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